Mechanisms of eukaryotic transcription

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Eukaryotic transcription initiation

Transcription is defined as the synthesis of RNA from a DNA template. In bacteria, transcription of all genes is catalysed by a single RNA polymerase, whereas in the eukaryotic nucleus, three different RNA polymerases — Pol I, Pol II and Pol III — carry out the synthesis of different classes of RNA. Pol I and Pol III transcribe a limited number of genes encoding ribosomal RNAs, transfer RNAs an...

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Molecular basis of eukaryotic transcription

The Nobel Prize in Chemistry for 2006 is awarded to Roger Kornberg for his fundamental studies of the molecular basis of eukaryotic transcription. Transcription is the process in a cell in which the genetic information stored in DNA is activated by the synthesis of complementary mRNA by enzymes called RNA polymerases. Eventually, the mRNA is translated by ribosomes into functional cell proteins...

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Molecular basis of eukaryotic transcription

The Nobel Prize in Chemistry for 2006 is awarded to Roger Kornberg for his fundamental studies of the molecular basis of eukaryotic transcription. Transcription is the process in a cell in which the genetic information stored in DNA is activated by the synthesis of complementary mRNA by enzymes called RNA polymerases. Eventually, the mRNA is translated by ribosomes into functional cell proteins...

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Gene expression is controlled by interactions between activators and coactivators. These interactions in turn are regulated by signaling pathways and by chromatin remodeling events. Recent studies indicate that the final arbiter of gene regulation is a coactivator scaffold at the promoter.

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Transcription Activation in Eukaryotic Cells

Transcription activation is the first step in eukaryotic gene expression. Gene regulation, which is about turning on and off expression of specific protein-coding genes in response to environmental changes, during development and in differentiated cells, widely occurs at the level of transcription activation. This is mostly achieved by DNA-binding proteins that can control the specificity of th...

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ژورنال

عنوان ژورنال: Genome Biology

سال: 2013

ISSN: 1465-6906

DOI: 10.1186/gb-2013-14-9-311